Single cell epigenomics is the study of epigenomics (the complete set of epigenetic modifications on the genetic material) in individual cells by single cell seq.
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What is the difference between genome and epigenomics?
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Genomics is the study of information that is encoded within the full DNA sequence complement of an organism. .....
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Epigenetics is the study of how DNA is organised and regulated in the cell to promote a stably heritable phenotype without alterations in the DNA sequence.
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Single-cell multi-omics has emerged as a powerful tech by which different layers of genomic output—and hence cell identity and function can be recorded simultaneously.
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Integrating various components of the epigenome into multi-omics allows for studying cellular heterogeneity for discovering molecular connectivity.
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Epigenomics Methods:
1. whole-genome single-cell bisulfite sequencing to measure DNA methylation, 2. whole-genome ChIP-sequencing to measure histone modifications, ...
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3. whole-genome ATAC-seq to measure chromatin accessibility and chromosome conformation capture.
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Human Epigenome Projec is a multinational science project, with aim to identify, catalog, and interpret genomewide DNA methylation patterns of all human genes.