Air pollution cause Lung Cancer

Reference: William Hill et al Nature, 2023

Analysis of clinical samples and mouse cancer models suggests that inflammation and a tumour-promotion process induced by air pollution.

William Hill et al. Nature studies of human lung samples and mouse cancer models that shed light on this issue.

The authors carried out a detailed analysis of the epidemiology of air pollution and its links to lung cancer in several groups of patients in the UK, South Korea, Taiwan and Canada.

Study propose that environmental particulate matter measuring ≤2.5 μm (PM2.5), known to be associated with lung cancer risk, promotes lung cancer.

They  found a significant association between PM2.5 levels and the incidence of lung cancer for 32,957 EGFR-driven lung cancer cases in four within-country cohorts.

To determine how air pollution causes cancer, the authors analysed the sequences of tumour DNA samples from non-smokers living in polluted areas.

Sequencing of DNA from biopsies of normal lung tissue from individuals, some of whom had been diagnosed with lung or other cancers, detected cells that carried EGFR or KRAS mutations in 18% and 53%, respectively.

These findings collectively support a tumour-promoting role for  PM2.5 air pollutants  and provide impetus for public health policy initiatives to address air pollution to reduce disease burden.

Reference: William Hill et al Nature

Lung adenocarcinoma promotion by air pollutants