Chimeric antigen receptor (CAR) T-cell therapy
What is this?

Chimeric antigen receptor T cells (CAR T cells) are T cells that have been genetically engineered to produce an artificial T cell receptor for use in immunotherapy.

Photo credit: Cancer Research UK

Chimeric antigen receptor (CAR) T-cell therapy represents a major advancement in personalized cancer treatment.

A type of treatment in which a patient's T cells are changed in the laboratory so they will attack cancer cells. T cells are taken from a patient’s blood.

Then the gene for a special receptor that binds to a certain protein on the patient’s cancercells is added to the T cells in the lab. The special receptor is called a chimeric antigen receptor.

CART-cell therapy is a way to get immune cells called T cells  to fight cancer by changing them in the lab so they can find and destroy cancer cells.

CAR T-cell therapy is also sometimes talked about as a type of cell-based gene therapy, because it involves altering the genes inside T cells to help them attack the cancer.

FDA approved CAR-TCell therapies

CAR T-cell therapy is available for some children with leukaemia and some adults with lymphoma.

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