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BeGenomics.com

How people develop tolerance to pain-relievers over time? Opioid Drug Tolerance!

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BeGenomics.com

Scripps Biomedical scientists have a discovered a key gene that is shedding light on how people develop tolerance to pain-relievers overtime

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For detail click here

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They used a forward genetic screen in Caenorhabditis elegans for unbiased identification of genes regulating opioid tolerance.

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They found that PTR-25/Ptchd1 controls μ-opioid receptor trafficking and that these effects were mediated by the ability of Ptchd1 to control membrane cholesterol.

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BeGenomics.com

Electrophysiological studies showed that loss of Ptchd1 in mice reduced opioid-induced desensitization of neurons in several brain regions.

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Mice and C. elegans lacking Ptchd1/PTR-25 display similarly augmented responses to opioids.

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Ptchd1 knockout mice fail to develop analgesic tolerance and have greatly diminished somatic withdrawal.

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The finding could open the door to a new generation of pain medications designed to function differently

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BeGenomics.com

The discovery raises the possibility that cholesterol in the cell membrane may affect how people respond to other drugs.

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BeGenomics.com

Understanding how cholesterol may drive tolerance is an important advance to find a new generation of pain medications less prone to causing overdose

BeGenomics.com

For detail click here

BeGenomics.com

How people develop tolerance to pain-relievers over time? Opioid Drug Tolerance!

www.BeGenomics.com

BeGenomics.com

How people develop tolerance to pain-relievers over time? Opioid Drug Tolerance!

www.BeGenomics.com

BeGenomics.com

How people develop tolerance to pain-relievers over time? Opioid Drug Tolerance!

www.BeGenomics.com

BeGenomics.com

How people develop tolerance to pain-relievers over time? Opioid Drug Tolerance!

www.BeGenomics.com