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What is Cancer Immunotherapy ?

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Cancer immunotherapy, also known as immuno-oncology, is a form of cancer treatment that uses the power of the body’s own immune system to prevent, control, and eliminate cancer.

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Immune cells, called tumor-infiltrating lymphocytes or TILs, are a sign that the immune system is responding to the tumor.

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  What are the types of immunotherapy?
1. Immune checkpoint inhibitors
2. T-cell transfer therapy
3. Monoclonal antibodies
4. Treatment vaccines

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Immunotherapy drugs have been approved to treat many types of cancer.

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Immunotherapy can cause side effects, many of which happen when the immune system that has been revved-up to act against the cancer also acts against healthy cells and tissues in your body.

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Different forms of immunotherapy may be given in different ways. These include: intravenous (IV), oral, topical and intravesical.

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Immunotherapy can “train” the immune system to remember cancer cells. This “immunomemory” may result in longer-lasting and potentially permanent protection against cancer recurrence.

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Examples of immune checkpoint inhibitors: Atezolizumab (Tecentriq)
Avelumab (Bavencio) Dostarlizumab (Jemperli)
Durvalumab (Imfinzi) Ipilimumab (Yervoy) Nivolumab (Opdivo) Pembrolizumab (Keytruda)

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T-cell transfer therapy is a type of immunotherapy that makes your own immune cells better able to attack cancer. There are two main types of T-cell transfer therapy: tumor-infiltrating lymphocytes  therapy and CAR T-cell therapy.

Reference: NIH-NCI and CRUK

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